Anybody has any update on the new Myostatin inhibitor for Pfizer which suppose to enter phase 2,please?
Any news about HT-100?

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I'd love to hear more about the Myostatin inhibitor as well.  Our new Neurologist mentioned our boys might be eligible for a new formulation Pfizer would be bringing to trial soon.

Could you please Andrew tell me what the opinion of your neurologist about this Myostatin inhibitor was?
I would like to put my son in this trial.

We didn't get into too much detail.  She just said that Pfizer had done some reformulation of the initial drug because of some side effects.  She did say that the kids she had on the previous version are doing very well.

Did you say Andrew that the kids on the last version of Myostatin inhibitor ACE 031 were doing very well or they are still doing very well even the trial was terminated?
Please,clarify.
Thank you very much

My impression, though I'm not sure she said exactly, was that the kids were off the drug, but still doing very well.

Thank you Andrew.in this case,I am going to put my son in the Pfizer trial at least to gain strength.please,accept my friendship

can you tell me what drug  will be in trial by  the Pfizer ?


Andrew Kerr said:

I'd love to hear more about the Myostatin inhibitor as well.  Our new Neurologist mentioned our boys might be eligible for a new formulation Pfizer would be bringing to trial soon.

I only know that it is a myostatin inhibitor,  I don't know the drug name.

Kenny Chuck said:

can you tell me what drug  will be in trial by  the Pfizer ?


Andrew Kerr said:

I'd love to hear more about the Myostatin inhibitor as well.  Our new Neurologist mentioned our boys might be eligible for a new formulation Pfizer would be bringing to trial soon.

Just to clarify some details, the Pfizer drug is not the same drug was that tested previously by Acceleron and Shire (ACE-031) or Wyeth's MYO-029.  This is a completely new drug that has never been tested in muscular dystrophy before and works on the same pathway but not exactly like the other two.  You can find more information here:  https://www.duchenneconnect.org/en/clinical-trials/study-faq-sheets...

Sharon

Thanks Sharon,

I see there is a Phase 1 that was completed.

When we saw our sons' Neurologist at B.C. Children's Hospital a few weeks ago, she seemed quite optimistic that there was going to be another trial (though I don't know what phase it would be) happening in the relatively near future.  She said she had a meeting planned with Pfizer, I believe sometime this year. 

She went as far as upping the boys to 18mg/day of Deflazacort from 12 because she wants them on a stable dose for the required amount of time if/when the trial is opened. 

On January they will start phase 2

Andrew, I believe that a Duchenne trial is planned and hopefully we will hear something about that soon.

Sharon

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