I received this msg from this research group
Thank you for your interest in our work.
I don't think that molsidomine is planned to be shortly used by AFM (Association Française contre les Myopathies) or MDA (Muscular Dystrophy
Association). Both associations privileged cell and gene therapies more than pharmacological therapy.
Nevertheless: the doctor which take care of your father can prescribe him Corvasal
Corvasal is frequently used in human. I can't give you any indication concerning the dose to used in human, I am not doctor in medecine.
In mice, we recently performed some tests with lower doses that the 10mg/kg/day used in the publication you known. We tried 5 , 2 and 1 mg/kg/day and the
results were good (the CK level was clearly reduced ) ".
They state that introducing NO could lead to an increase in utrophin and a regression of the dystrophic phenotype. I do not understand why there are no trials of this drug or another NO donor, such as Isosorbide.