Inhibiting myostatin reverses muscle fibrosis through apoptosis.

Hi Dear Parents;

I came across this item on myostatin and thought,well, most of us have heard or read something on mysostatin at one time or the other.Still i think i good i share. Am i reading it wrong or would it mean that muscle lost to fibrosis and may be turned to connective tissue could be salvaged thro myostatin inhibition?Check out link below.Thanks.

http://www.ncbi.nlm.nih.gov/pubmed/22685331

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Permalink Reply by Jason Darienzo on September 10, 2012 at 3:58pm

Does anyone have access to the full article?

Permalink Reply by wainaina muiruri on September 11, 2012 at 5:08am

I am yet to come across the full version of this article.May be one of the other parents have.Th

anks.

Permalink Reply by Evrim Argun on September 12, 2012 at 11:41am

Here is the full article

Permalink Reply by Evrim Argun on September 12, 2012 at 1:42pm

Finally attached the article..

Attachments:
Permalink Reply by Anna Mossiat on September 22, 2012 at 6:11am

Am I mistaken or could this potentially be a cure? If the damage can be reversed then surely that eliminates one of the biggest if not THE biggest problem with MD?

Permalink Reply by Keith Van Houten on September 22, 2012 at 12:38pm

Interesting.  I don't get too excited over MDX mouse studies, though.  Lots and lots of steps between there and a human trial.

Is PTC the only company working on myostatin inhibition?  PPMD's therapeutic pipeline shows that candidate in the "optimization" phase.

Permalink Reply by Jason Darienzo on September 22, 2012 at 5:24pm

Pfizer has started phase 1 trials on a myostatin inhibitor.

http://clinicaltrials.gov/ct2/show/NCT01616277

Permalink Reply by Keith Van Houten on September 22, 2012 at 6:12pm
Thanks!
Permalink Reply by wainaina muiruri on September 24, 2012 at 2:53am

With Pfizer already working clinical trials on safety and tolerability of a myostatin inhibitor,looks like that front is being well taken care of.Let us just pray something comes out of it,and not in the long run.

Permalink Reply by Jon Moulton on September 24, 2012 at 12:10pm

This is a straightforward target for a Morpholino oligo.

For examples, see pubs.gene-tools.com and search for "myostatin".

If the Pfizer approach doesn't work out, there's a backup.

Permalink Reply by Jason Darienzo on September 25, 2012 at 4:23pm
Permalink Reply by wainaina muiruri on June 14, 2014 at 9:32am

Inhibiting myostatin reverses muscle fibrosis through apoptosis.

Research demonstrates that skeletal muscle fibrosis can be pharmacologically reversed
through induction of fibroblast apoptosis.

Please follow this link: jcs.biologists.org/content/125/17/3957.full.pdf

Research Team: Zhao Bo Li1, Jiangyang Zhang and Kathryn R. Wagner

Center for Genetic Muscle Disorders, Hugo W. Moser Research Institute at Kennedy Krieger Institute, 707 North Broadway, and Departments of Neurology,Neural Science.
The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
*To get in touch with the Author for Correspondence (wagnerk@kennedykrieger.org)
Accepted 23 April 2012
Journal of Cell Science 125, 3957–3965

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