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Started this discussion. Last reply by Ofelia Marin Sep 24, 2009. 4 Replies 0 Favorites
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Could you please send me your mailing address so I can send you a thank you note for your sweet gift? (If you'd like to e-mail me, please send an e-mail to firstname.lastname@example.org.)
I hope you are doing well. We're hanging in there.
Hey Donna, was thinking about you guys not to long ago. That is wonderful news that Jordan is doing well. I didn't realize he was a junior already. Will he be able to drive? We just got back from Dr Wongs last week, they said Jonluke was stable, but he hasn't grown in height at all in a year. They recomend him taking the growth hormone, and right now Dr Wong is doing study on them. She asked us to be in the study and every thing would be paid for. DId Jordan take them? Also we started the heart meds, they said he had a little fibrosis and we should start. He did well in the timed test they said he timed like a normal kid. THe PT said he was tight in the ham strings and finger flexors. We haven't been to good at the stretching but are starting back on it. How about Jordan does he do the stretching regularly? How about the night splints? Jonluke hates to wear them. I'm so happy that Jordan is doing so well, gives me more hope for Jonluke. Jonluke is doing well physically, he just started 6th grade at a new school. He has a rolling back pack this year which makes it so much easier, they would not let him have one in Elementary. Hope I didn't ask to many questions, Keep in touch
So, ACE-031 really is different from MYO-029 in that it blocks the entire pathway that myostatin was just one part of...it turns out that there is probably a whole group of molecules out there like myostatin that can put the brakes on muscle growth, If you block myostatin you get some effect, but you still have those other molecules out there doing their thing. But all of these molecules use the same cell receptor so if you block the receptor instead you take them all out with one fell swoop. That's what ACE-031 does. If you compare it directly in the mice to just blocking myostatin you get signficantly more muscle mass by blocking the receptor.
One encouraging thing is that in the trial of ACE-031 in healthy volunteers the volunteers saw a significant increase in lean muscle mass. It's not clear that this was the case with Wyeth's MYO-029 drug. I
I appreciate your getting back to me. I'm sure you have a lot on your plate.
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