My son, Joseph is the middle child in our family and is 12. Our youngest, Ashley, is 6 and doesn't seem to be too affected by her brothers disease (which has truly been a blessing in our family). Our oldest, Samantha, is 14 and has watched the progression of her little brother. It has been the hardest on her, I feel because she knows what it used to be like for him and also understands what the f…