Like at least some of you, I've wondered about Dr. Sweeney's comments about exon skipping not helping boys with deletions at exon 44, like my son and that of whoever it was (not me or Cheryl) that asked him the question. There are members of our little sub club here whose kids have multiple deletions that are predicted to be "in frame" according to the on line widgets like the one from the University of Utah ( http://www.genome.utah.edu/DMD/deletion_worksheet/
) or Robin Sharp's ( http://www.dmdregistry.org/reports/predictor/
). I'm now wondering if the assumption of a lot of us that our boys will be better off if they have an in frame, truncated dystrophin is really accurate.