Anyone putting their child into this trial?

I thought it was mainly for helping the heart, but they must think it helps with walking.

"The main purpose of this study is to determine if tadalafil can slow the decline in walking ability of boys who have Duchenne muscular dystrophy (DMD)."

Does anyone know anything about phase 2? Can't seem to find the results.

Also, does anyone have reservations about tadalafil? Scare stories? 

I'm going to try and get my son into the Oxford trial.

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Hi Phil, my son will be 7 in a couple of weeks and we are considering this too. There is no phase 2 trial with tadalafil, this is an already approved drug that they will be doing a one and done trial for. The basis for the this trial was a similar one done with beckers, results showed that daily dosing restored muscle function to near normal levels. The drug provides nitric oxcide to the muscles which is essential for muscle cell integrity. My concern is being randomized into the placebo group.

"The basis for the this trial was a similar one done with beckers, results showed that daily dosing restored muscle function to near normal levels."

That's very encouraging Chris.

The chance of getting a placebo is always a concern, but hopefully there are positive results. Good luck.

Hi Chris, you wrote that there was a similiar trial with Beckers. If results have been such positive, why wasn't there an approval for it?! Can you send me a link to this old trial? 

Good luck to both of you for being part of this promising trial!

Thanks Simone

hi, I took my son to a clinical site to see if he qualifies it will it will be a week or two before we know if he qualifies, don't know if I'm taking the right approach, he is 8 years and some change with a point mutation in exon 31, never been In a clinical trial just hope that I'm making the right decisions, and my concerns are that if it will accelerate the course of the disease including the heart like it did with the Viagra trial

I'm also concerned about accelerating the disease with respect to the heart.. but that's what trials are for. I think of the many children in the past who went through a lot of suffering to get us to where we are now. Now it's our childrens turn. Very hard decision to make.

juan banuelos said:

hi, I took my son to a clinical site to see if he qualifies it will it will be a week or two before we know if he qualifies, don't know if I'm taking the right approach, he is 8 years and some change with a point mutation in exon 31, never been In a clinical trial just hope that I'm making the right decisions, and my concerns are that if it will accelerate the course of the disease including the heart like it did with the Viagra trial

hi

where can I get the  tadafil becker trial results, dosis etc?

Hi,

Was Viagra trial terminated because it accelerated disease progress?

Please,where did you read this?

I know that it was terminated,but I thoought because it was ineffective!

The trial original trial with 10 patients was done at cedars-Sinai. The article in the Wall Street Journal appears Nov 28th, 20012, "Cialis shows promise in Rare Muscle disease" You can google Tadalafil + Beckers MD and numerous articles will come up.

hi everyone, I just had a phone call from a clinical site and my son did qualified and I'm planning on moving forward, like I said there was a trial with Viagra in older DMD patients, and it was stopped they think it was the course of the disease and not the drug or the possibility of the drug, not sure. Cialis is in the same family as Viagra, so who knows if I'm making the right decision peoples thoughts and input will be greatly appreciated

That trial did not show that "daily dosing restored muscle function to near normal levels."  The patients didn't even get daily dosing.  It was a single dose trial. 



Chris Diemler said:

The trial original trial with 10 patients was done at cedars-Sinai. The article in the Wall Street Journal appears Nov 28th, 20012, "Cialis shows promise in Rare Muscle disease" You can google Tadalafil + Beckers MD and numerous articles will come up.

Sorry Keith, I am still trying to relocate the article w/ that quote, its been almost a year i believe since it came out. Not trying to put any mis information out there and have no idea if this is a therapy that will work.

keith what trial are you talking about?  the Cialis or the Viagra trial? there is plenty of articles that shows that in beckers a single dose normalized blood flow etc. also there are videos on you tube " ron victor dmd" will probably pull a list of vidoes. so what are youre thoughts on this trial?

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