More details in the paper about improved in DMD from Stem Cells

I think this paper talks about Ryan Benton and his Costa Rica injections. THe company involved is MediStem. There also have been recent reports of Medistem being aquired.

 

 

This also gives a lot of historical information so a good informative reading, at the least.

 

Quotes from the paper

The increments in muscle strength after the two stem cell administration appeared to be additive, with most benefit recorded after the second. Upper extremity improvement in strength evolved from the incapacity to lift against gravity before the transplantation towards the ability to lift 2 lbs weights after the procedure.

 

 

 

A muscle biopsy taken in January 2009

demonstrated normal (>50%, normal = 50-100% expression of normal-molecular size)

levels of muscular dystrophin.

 

 

 

http://www.cellmedicine.com/doc/Mesenchymal%20stem%20cells%20as%20a... .

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This is the first time I've seen a 'proper' looking academic paper concerning stem cell therapy for DMD. Does anyone know more of these people/this research?
Wow! Thanks for finding this Tulika!!! I was wondering when stuff from Costa Rica was going to reach us, and boy does it look good. You mentioned Medlstem being purchased, do you know by whom? Is there any other info you have on this approach?
Entest is to acquire Medistem. News about 2 weeks old


http://www.marketwire.com/press-release/Entest-Biomedical-Announces...



cheryl cliff said:
Wow! Thanks for finding this Tulika!!! I was wondering when stuff from Costa Rica was going to reach us, and boy does it look good. You mentioned Medlstem being purchased, do you know by whom? Is there any other info you have on this approach?
Thanks Tulika.
I did a little digging and the Medistem website is functional but when looking into the "honors" & "media/news release" sections there are areas left void. Plus there is no listed intent to fight Duchenne, unlike other disease they list as potential targets for their stem cell product. Their San Diego address appears to be legit, ie off campus at UCSD/ in an office-industrial area of SD, near other biotech's. If you read the news releases provided, the articles written offer contradictory opinions by legit scientists (ie a scientist from Scripps stated she believed Medistem has a long way to go to prove their claims).

The claims sound pretty good...perhaps it is a little early in the game for Medistem? Any thoughts?
Defenitely its too early to call victory. There are too many folks commited to finding a cure for DMD. They must have already explored every possible thing about this claim or the company.

Dont know if its the optimistic part of me or somethign else. This claim does give me lot of hope.
This is among the worst paper Ive ever seen in a "proper" academic journals. im shocked it made it through review with the scant primary data. Im tempted to write the editor. Mostly big claims, little data and review of the literature. I dont feel like the paper provides any data that can be evaluated objectively.

carrie
Carrie,
Good point. I am not very familiar with stem cell based papers. Do you have some example against which one can evaluate this one

carrie said:
This is among the worst paper Ive ever seen in a "proper" academic journals. im shocked it made it through review with the scant primary data. Im tempted to write the editor. Mostly big claims, little data and review of the literature. I dont feel like the paper provides any data that can be evaluated objectively.

carrie
Did anyone see "60 Minutes" on Sunday about stem cell fraud? Here is a link to the program and other useful info about stem cells. http://www.cbsnews.com/video/watch/?id=6408474n&tag=cbsnewsMain... Since we are all so hopeful for a cure for DMD we must carefully evaluate all claims not endorsed by legitimate researchers. This program does not specifically speak of DMD, but ALS victims, but the point is to be cautious.
Carrie,

I agree, this is a poor paper - or perhaps a paper that presents poor research - one case proves nothing - we all know that. At the same time, I hope it is research that has legs. I am assuming that there is a goal with this sort of preliminary work of generating interest and funds to research further and eventually move to a larger study/trial.

I was interested in the inflammation info in this paper - that seems pretty compelling. I was also encouraged by the variety of sources listed for mytochondrial stem cells. I am a layperson, but that was news to me - and it seemed like pretty good news.

In the end, I think this is the only technology that will truly cure our boys. So, yes, it's a bad paper, but I am really rooting for these guys!

carrie said:
This is among the worst paper Ive ever seen in a "proper" academic journals. im shocked it made it through review with the scant primary data. Im tempted to write the editor. Mostly big claims, little data and review of the literature. I dont feel like the paper provides any data that can be evaluated objectively.

carrie
I am rooting for stem cells too.

carrie

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