Inhibiting myostatin reverses muscle fibrosis through apoptosis.

Hi Dear Parents;

I came across this item on myostatin and thought,well, most of us have heard or read something on mysostatin at one time or the other.Still i think i good i share. Am i reading it wrong or would it mean that muscle lost to fibrosis and may be turned to connective tissue could be salvaged thro myostatin inhibition?Check out link below.Thanks.

http://www.ncbi.nlm.nih.gov/pubmed/22685331

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Does anyone have access to the full article?

I am yet to come across the full version of this article.May be one of the other parents have.Th

anks.

Here is the full article

Finally attached the article..

Attachments:

Am I mistaken or could this potentially be a cure? If the damage can be reversed then surely that eliminates one of the biggest if not THE biggest problem with MD?

Interesting.  I don't get too excited over MDX mouse studies, though.  Lots and lots of steps between there and a human trial.

Is PTC the only company working on myostatin inhibition?  PPMD's therapeutic pipeline shows that candidate in the "optimization" phase.

Pfizer has started phase 1 trials on a myostatin inhibitor.

http://clinicaltrials.gov/ct2/show/NCT01616277

Thanks!

With Pfizer already working clinical trials on safety and tolerability of a myostatin inhibitor,looks like that front is being well taken care of.Let us just pray something comes out of it,and not in the long run.

This is a straightforward target for a Morpholino oligo.

For examples, see pubs.gene-tools.com and search for "myostatin".

If the Pfizer approach doesn't work out, there's a backup.

Inhibiting myostatin reverses muscle fibrosis through apoptosis.

Research demonstrates that skeletal muscle fibrosis can be pharmacologically reversed
through induction of fibroblast apoptosis.

Please follow this link: jcs.biologists.org/content/125/17/3957.full.pdf

Research Team: Zhao Bo Li1, Jiangyang Zhang and Kathryn R. Wagner

Center for Genetic Muscle Disorders, Hugo W. Moser Research Institute at Kennedy Krieger Institute, 707 North Broadway, and Departments of Neurology,Neural Science.
The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
*To get in touch with the Author for Correspondence (wagnerk@kennedykrieger.org)
Accepted 23 April 2012
Journal of Cell Science 125, 3957–3965

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