78 patients with Duchenne muscular dystrophy (DMD) aged 3 to 18 years, including three girls, were observed at EmCell clinic. In all cases, the diagnosis was confirmed by genetic analysis.
The stem cell treatment began at different stages of the disease, and the patients differed in the degree of muscle atrophy and ability to move (bedridden, in wheelchairs and walking). Patients were administered mesenchymal, ectodermal and endodermal stem cells derived from germ layers of systems and organs of 5-8-week old embryos. Administered dose ranged from 0.5 to 3 ml, the stem cell content equaled 0.1-100*105/ml.
Our conclusions are based on a nine-year observation of the DMD patients that were treated with stem cells. Within the first two months after the stem cell transplantation, strength of various muscle groups in these patients increased by 100-700% and remained high during 8 to 15 months. In addition, patients’ motor skills improved, depending on the stage of the disease. For example, patients at the second stage of the disease had their walking ability improved. Their ability to rely on the heel and walk up/down the stairs increased, and foot lifting became more confident. Moreover, they had increased ability to tolerate the daily stress.
During the first two weeks after the transplantation, the activity of certain blood enzymes increased, and it markedly decreased or even returned to normal over the following 4-5 weeks. Usually, this effect persisted for 2 to 5 months. There was also a reduction in pseudo hypertrophy and tention of forearm and calf, contracture of knee and ankle joints, the manifestations of myocardiopathy and respiratory failure, especially in patients at the stage IVa-IVb.
Duchenne muscular dystrophy patients need continuous stem cell treatment (at least once every 6-8 months) to stop progression of muscle atrophy. Treatment cessation leads to the further disease progressing and physical activity limitation. Regardless of the stage of the disease, stem cell transplantation stops DMD development and leads to significant improvement in the patient's condition. Among other things, the cellular immunity is restored and cytotoxic activity of mesenchymal cells is reduced.
wow! what is the article source and where this experiment has performed?
Sounds interesting.But from what i have read and heard on stem cells,seems like its a science still in its infancy and concerns of risks to patients have been raised in various quarters.
the website is:http://www.emcell.com/
It does sound promising but from the research I have done a single treatment averages $30,000 and thats not including airfare and hotel accom.
http://www.emcell.com/ I have called them regarding the cost of the therapy. They said 1 session is 10.000 $ They use 5-8 weeks of embrio stem cells. As I know ebrio stem cells are very high differentiative cells which one of the complications is brain tumor. What do you think is it safe to go for this therapy? ANy other complications?
I think there are no. of discussions on this topic on ppmd site. One such link for this topic is http://community.parentprojectmd.org/forum/topics/embryonic-stem-ce.... People from our community has interacted with them earlier. Am not sure if something has changed. There is a stem cell study for DMD on clinicaltrials.gov. Link is http://clinicaltrials.gov/ct2/show/NCT01610440?term=DMD+stem+cell&a.... Probably we can check that and rely on their protocol. Estimated completion is within a year from now.
Watch this 60 Minutes story as part of your research on stem cell procedures...
I replied to the clinical trial on clinicaltrials.gov. It is a study being done in China. They are not recruiting outside of china due to the consiatent monitoring over a year. They did however give me information about the organization they are doing the clinical study through. http://stemcellschina. com and http://wwwbeikebiotech
Im not jumping on a plane tomorrow nor do I have the $ to do so but I did find this interesting!
Mayana Zatz, very respected doc in Brazil is doing some research on adipose (fat) stem cell transplantation too that is very exciting. Alas, Google has no results that I can find or even details on when they may arrive.
I agree with Keith that in this particular area more skepticism is warranted than usual. The two words "stem cell" deliver such powerful hopes that you can be sure there are more charlatans waiting for your money than sincere medical programs.
Every parent who has the means to afford regular treatments has to decide based on their own "desperation meter" whether these treatments are worth the risk. Keep in mind you will almost certainly sign away any legal rights you have when you get such a procedure.
What about cord blood stem cells? Does anyone know if anyone is using that? I wonder if stem cells from the cord blood of a leatlhy sibling would be comparable?