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Any development in curing exons 18-25 ?

As i know the medicines AVI, PRO etc. can treat exons 45-52, so anybody here knows the how far this medicines can cure DMD ? or how successful of these medicines ?

My son is defined with deletion of exons 18-25. Any curing for this case ?

Please help me.

Thanks

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Permalink Reply by christine good on January 10, 2011 at 11:40pm

Exon skipped	Potentially Repairable Deletions
51	45-50, 47-50, 48-50, 49-50, 50, 52
50	51, 51-53, 51-55
45	12-44, 18-44, 44, 46-47, 46-48, 46-49, 46-51, 46-53, 46-55
53	10-52, 45-52, 46-52, 47-52, 48-52, 49-52, 50-52, 52
44	10-43, 19-43, 30-43, 35-43, 36-43, 40-43, 42-43, 45, 45-54
8	4-7, 5-7, 6-7, 3-7
55	47-54, 48-54, 49-54, 50-54, 52-54, 54, 56, 56-62
7	2-6,8-11, 8-17, 8-43, 8-45
52	53, 53-55, 53-57, 53-59, 53-60
17	12-16, 18, 18-20, 18-22, 18-25, 18-27, 18-29, 18-33, 18-36, 18-38, 18-41, 18-44

Hope this helps.

Christine

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Permalink Reply by Rahul Grover on January 12, 2011 at 11:30pm

Hi, I believe your son would benefit from skipping exon 17.

The trials so far being conducted are on skipping exon 44, and 51.

We are all hopeful these trails will be successful, and skipping of other exon will follow.

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Permalink Reply by Nguyen Van Anh on January 12, 2011 at 11:40pm

Dear Rahul,

Yes, I think so. And if you know someone with the same requirement with exon 17, please let me know. Thank you
Rahul Grover said:

Hi, I believe your son would benefit from skipping exon 17.

The trials so far being conducted are on skipping exon 44, and 51.

We are all hopeful these trails will be successful, and skipping of other exon will follow.