We took my son ( 3 years old) to a therapist that cheked the aminoacids in his blood. We have found that he was below the normal levels in almost all the aminoacids (aspartic acid, GABA, cystine, phosphoethanolamine, glutamine, hydroxiproline, hydroxilysine-1, lysine, 1-methylhystidine, ornitine, proline, serine and tyrosine). Its curious because normally the recommended (whitout any proof) aminoacids supplements for DMD are glutamine, arginine(*) and taurine. His levels of Arginine and Taurine were OK but not glutamine. Based on this aminogram analysis he recommend him to take 500 mg lysine and 500 mg of proline int morning and 500 mg cysteine with 500 mg ornitine in the evening. We also decided to give him glutamine because its the main aminoacid in the muscle and its als a precursor of GABA that is a neurotransmisor. I have searched in internet but I didn't find references about analysing aminoacids in DMD boys, I think that this is the best way to know which aminoacid to give to our sons.

 

(*) There is a study that says that arginine increas fibrosis on MDX mice.

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This is purely anecdotal evidence, but we recently stopped my son's l-arginine supplements when a small area of fibrosis showed up on his cardiac MRI.  He's only 8.

 

I don't know a thing about any of the other amino acids, but am very curious about them.


In June we will make the same analysis again and we will see if is amino acid levels improved.


Nelini Sawh said:

Has there been any success with this?
Hi Ofir ,i would be very interested to hear the outcome,,have you noticed any benefits yourself since changing the amino acids that you give him??In addition i am curious about liver tablets,any thoughts??

Hi Clare, When I will have the results I will post them, its interesting that a lot of people is giving aminoacids but I know about nobody that analyse them. My son Eyal is only 3 and a half so by now is difficult to see any change. What I would like to know is if the lack of aminoacids that he has is due to DMD or not. I don't have any idea about liver tablets, but I'm interested about supplements.


Clare Harper said:

Hi Ofir ,i would be very interested to hear the outcome,,have you noticed any benefits yourself since changing the amino acids that you give him??In addition i am curious about liver tablets,any thoughts??

I am in the process of looking into this as well.  I asked for an amino acid test and will be getting one this week.  My concern is that the Neuro specialist at CHOP here in Philadelphia said the test can be variable depending on what the patient eats and not a good marker.  I have been searching and haven't found much information about Amino Acid tests.  If you find anything, please let me know!!

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