I was going through the acceleron website for details on ACE-031. As per the information available on their website, ACE-031 is shown to help grow muscles which have HIGHER UTROPHIN Levels.
So it mean that ACE-031 can help in growing STRONG MUSCLES WHICH HAVE HIGHER UTROPHIN LEVELS ALSO.
To quote from the information available at http://www.acceleronpharma.com/content/products/ace-031/duchenne.jsp
Importantly, the composition of muscle produced by ACE-031 treatment is distinct from that of dystrophin-deficient muscle. Utrophin is a protein that is related and serves a function similar to normal dystrophin, but unlike dystrophin, it is only produced during fetal development. Increasing adult production of utrophin could potentially compensate for loss of strength and function due to defective dystrophin. In adult mdx mice, ACE-031 treatment increases the expression of utrophin, which may contribute to the significantly increased muscle strength observed in these animals.
ACE-031 Treatment Increases Utrophin Expression in MDX Mice".
As such this is very encouraging news but I was not able to understand how is that achieved. I was under the impression that ACE-031 is protein therapeutic that builds muscle and increases strength by inhibiting signaling of a cell surface receptor called the activin receptor type IIB (ActRIIB).How it is able to increase UTROPHIN levels also? Has anyone got any clarifications here.
Thanks Lori for this update.
Wow!!! That's amazing. So as such it provides all the things we are looking for.Also, ACE-031 will help bigger MD population ( apart from helping all DMD kids, my guess is that it will help BMD kids also).
I think PH2 has already started in Canada and enrollment will be completed by AUG END.
We start in August! Joshua is going to be a part of it!