Dose anyone know if this will be useful for our boys


CAMBRIDGE, Mass. – October 20, 2008 - Acceleron Pharma, Inc., a biopharmaceutical company developing novel therapeutics that modulate the growth of tissues including bone and muscle, today announced the initiation of a Phase 1 clinical study of ACE-031, its lead compound for treating diseases involving the loss of muscle mass and function. The Phase 1 trial is a randomized, placebo-controlled single-dose, dose-escalating study to evaluate the safety and pharmacokinetics of ACE-031. This clinical trial is the first-in-human study in the global development of ACE-031 and will be conducted in Canada.

“There is a tremendous unmet medical need to treat patients suffering from a wide array of diseases involving the loss of muscle strength and function. ACE-031 has the potential to be a very important new approach to treat these serious and life-threatening conditions,” said Matthew Sherman, M.D., Chief Medical Officer of Acceleron.

“The start of this ACE-031 Phase 1 trial is another important clinical milestone for Acceleron,” said John Knopf, Ph.D., Chief Executive Officer of Acceleron. “Last week we announced the start of a Phase 2 clinical trial in patients with multiple myeloma bone disease with ACE-011, the lead compound in our bone program, and today we are proud to announce the start of the first clinical trial for ACE-031, the lead compound in our muscle program. The Acceleron pipeline continues to mature and expand, and most notably, the company remains in a strong financial position to deliver on our clinical goals. We look forward to several data presentations at major medical meetings before the end of the year that will demonstrate the progress of our pipeline.”

Muscle is increasingly recognized as central to many biological processes and plays a major role in human health. The loss of muscle mass and strength is ultimately directly related to the cause of death in neuromuscular diseases such as muscular dystrophy and amyotrophic lateral sclerosis (ALS). Severe muscle loss in cancer leads to serious complications and a poor prognosis. Muscle loss is a natural consequence of aging, similar to bone loss, resulting in decreased muscle strength (frailty), reduced mobility and an increased risk of a fall and broken bones. In metabolic diseases, an imbalance of diet, energy utilization and skeletal muscle leads to poor metabolic function. By increasing muscle mass there is a corresponding decrease in fat mass and improvements in metabolic function.

About ACE-031

ACE-031, a soluble molecule based on the activin receptor type IIB (ActRIIB), is a biologic therapeutic that inhibits signaling through the ActRIIB receptor. By blocking signaling though ActRIIB, ACE-031 increases muscle mass and strength. In numerous and varied animal models of disease, ACE-031 significantly increased muscle mass and muscle strength. ACE-031 has shown encouraging preclinical results in animal models of age-related muscle loss, neuromuscular disease, cancer treatment-related muscle loss and metabolic diseases.

About Acceleron

Acceleron is a privately held biopharmaceutical company committed to discover, develop, manufacture and commercialize novel biotherapeutics that modulate the growth of bone, muscle, fat and the vasculature to treat musculoskeletal, metabolic and cancer-related diseases. Acceleron’s scientific approach takes advantage of its unique insight into the regenerative powers of the Growth and Differentiation Factor (GDF) family of proteins. ACE-011, a novel bone forming compound, is the Company’s lead compound and is being developed to reverse bone loss in diseases such as cancer-related bone loss in a strategic alliance with the multinational biopharmaceutical company Celgene Corporation. ACE-031, a novel muscle building compound, is being developed to increase muscle mass and strength. In addition, the company is advancing through preclinical development product candidates that control angiogenesis and inhibit fat accumulation. Acceleron utilizes proven biotherapeutic technologies and capitalizes on the company’s internal Good Manufacturing Practice (GMP) manufacturing capability to rapidly and efficiently advance its therapeutic programs. The investors in Acceleron are Advanced Technology Ventures, Bessemer Ventures, Flagship Ventures, MPM BioEquities, OrbiMed Advisors, Polaris Ventures, QVT Financial, Sutter Hill Ventures and Venrock. For more information, visit www.acceleronpharma.com.

CONTACT:
Acceleron Pharma:
Steven Ertel, 617-649-9234
Vice President, Corporate Development

Paul Kidwell (Media)
Suda Communications LLC, tel: 617-296-3854

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Inhibits myostatin, so it would help our boys if proven therapeutic.
Hi,
It will be interesting to see this unfold. Myostatin inhibition has been discussed for a very long time. The Wyeth trials (using the myostatin antibody) did not prove to be useful, though we are hopeful ACE 031 demostrates efficacy.
Pat
Just found this on the website

Dose anyone have any further updates



Acceleron to Present ACE-031 Preclinical Study Results as Treatment for Loss of Muscle Mass and Function

CAMBRIDGE, Mass. – June 10, 2009 - Acceleron Pharma, Inc., a biopharmaceutical company developing novel therapeutics that modulate the growth of cells and tissues including red blood cells, bone, and muscle, today announced it will provide three oral presentations on data from its ACE-031 program at the Endocrine Society’s 91st Annual Meeting to be held in Washington, DC from June 10-13, 2009. The presentations will provide results from preclinical studies highlighting the effects of its lead investigational product for treating diseases involving the loss of muscle mass and function.
released today


Acceleron Pharma’s ACE-031 Increases Lean Body Mass in Phase 1 Single Dose Clinical Trial
Data to be Presented at the 14th International Congress of the World Muscle Society

Company Initiates ACE-031 Phase 1 Multiple Dose Clinical Trial

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Acceleron Pharma, Inc., a biopharmaceutical company developing novel therapeutics that modulate the growth of cells and tissues including red blood cells, bone, and muscle, today announced preliminary results from the ACE-031 Phase 1 single dose clinical trial indicating that ACE-031 was safe and well-tolerated at all dose levels and increased lean body mass. The results from this randomized, placebo-controlled study will be presented at the 14th International Congress of the World Muscle Society taking place in Geneva, Switzerland, September 9-12, 2009. In addition, Acceleron announced that it has initiated a multiple dose Phase 1 clinical trial for ACE-031.

"We are excited to share these encouraging results from our ACE-031 Phase 1 single dose clinical trial at the World Muscle Society meeting next week. Preliminary results show increases in lean body mass and muscle volume as well as positive effects on bone and fat,” said Matthew Sherman, M.D., Chief Medical Officer at Acceleron. “Based on the promising results of this Phase 1 single dose clinical trial, we have initiated a multiple dose study of ACE-031 in healthy volunteers.”

“ACE-031 continues to demonstrate enormous clinical potential as a treatment for patients suffering from neuromuscular diseases such as muscular dystrophy and amyotrophic lateral sclerosis (ALS),” said John Knopf, Ph.D., Chief Executive Officer of Acceleron. “In addition, targeting muscle and adipose tissue with our related ACE-435 compound holds great promise to treat a wide range of diseases including cancer cachexia, metabolic diseases and age-related muscle loss. I’m proud of Acceleron’s leadership in the field of targeting muscle to treat disease, which is an area that we believe holds great promise.”

Muscle is increasingly recognized as central to many biological processes and plays a major role in human health. The loss of muscle mass and strength is ultimately directly related to the cause of death in neuromuscular diseases such as muscular dystrophy and amyotrophic lateral sclerosis. Severe muscle loss in cancer leads to serious complications and a poor prognosis. Muscle loss is a natural consequence of aging, similar to bone loss, resulting in decreased muscle strength (frailty), reduced mobility and an increased risk of a fall and broken bones. In metabolic diseases, an imbalance of diet, energy utilization and skeletal muscle leads to poor metabolic function. By increasing muscle mass there is a corresponding decrease in fat mass and improvements in metabolic function.

About ACE-031

ACE-031, a soluble fusion protein based on the activin receptor type IIB (ActRIIB), is a biologic therapeutic that inhibits signaling through the ActRIIB receptor. By preventing signaling through ActRIIB, ACE-031 increases muscle mass and strength. In numerous and varied animal models of disease, ACE-031 significantly increased muscle mass and muscle strength. ACE-031, and a related molecule ACE-435, have shown encouraging preclinical results in animal models of age-related muscle loss, neuromuscular disease, cancer treatment-related muscle loss and metabolic diseases. ACE-031 is currently being studied in a Phase 1 multiple dose clinical trial in healthy volunteers. ACE-435 is expected to enter clinical trials in 2010.

About Acceleron

Acceleron is a privately held biopharmaceutical company committed to discover, develop, manufacture and commercialize novel biotherapeutics that modulate the growth of red blood cells, bone, muscle, fat and the vasculature to treat musculoskeletal, metabolic and cancer-related diseases. Acceleron’s scientific approach takes advantage of its unique insight into the regenerative powers of the TGF-beta superfamily of proteins. ACE-011 is currently being studied in two Phase 2 clinical trials in cancer patients. ACE-031 is currently being studied in a Phase 1 clinical trial in healthy volunteers. In addition, the company is advancing new product candidates that increase muscle mass, control angiogenesis, inhibit fat accumulation and increase hemoglobin. Acceleron utilizes proven biotherapeutic technologies and capitalizes on the company’s internal GMP manufacturing capability to rapidly and efficiently advance its therapeutic programs. The investors in Acceleron include Advanced Technology Ventures, Bessemer Ventures, Celgene, Flagship Ventures, MPM BioEquities, OrbiMed Advisors, Polaris Ventures, QVT Financial, Sutter Hill Ventures and Venrock. For more
Thanks for posting. It will be interesting to hear what Pat has to say after going to the World Muscle Society Meeting next week.

R Patel said:
released today


Acceleron Pharma’s ACE-031 Increases Lean Body Mass in Phase 1 Single Dose Clinical Trial
Data to be Presented at the 14th International Congress of the World Muscle Society

Company Initiates ACE-031 Phase 1 Multiple Dose Clinical Trial

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Acceleron Pharma, Inc., a biopharmaceutical company developing novel therapeutics that modulate the growth of cells and tissues including red blood cells, bone, and muscle, today announced preliminary results from the ACE-031 Phase 1 single dose clinical trial indicating that ACE-031 was safe and well-tolerated at all dose levels and increased lean body mass. The results from this randomized, placebo-controlled study will be presented at the 14th International Congress of the World Muscle Society taking place in Geneva, Switzerland, September 9-12, 2009. In addition, Acceleron announced that it has initiated a multiple dose Phase 1 clinical trial for ACE-031.

"We are excited to share these encouraging results from our ACE-031 Phase 1 single dose clinical trial at the World Muscle Society meeting next week. Preliminary results show increases in lean body mass and muscle volume as well as positive effects on bone and fat,” said Matthew Sherman, M.D., Chief Medical Officer at Acceleron. “Based on the promising results of this Phase 1 single dose clinical trial, we have initiated a multiple dose study of ACE-031 in healthy volunteers.”

“ACE-031 continues to demonstrate enormous clinical potential as a treatment for patients suffering from neuromuscular diseases such as muscular dystrophy and amyotrophic lateral sclerosis (ALS),” said John Knopf, Ph.D., Chief Executive Officer of Acceleron. “In addition, targeting muscle and adipose tissue with our related ACE-435 compound holds great promise to treat a wide range of diseases including cancer cachexia, metabolic diseases and age-related muscle loss. I’m proud of Acceleron’s leadership in the field of targeting muscle to treat disease, which is an area that we believe holds great promise.”

Muscle is increasingly recognized as central to many biological processes and plays a major role in human health. The loss of muscle mass and strength is ultimately directly related to the cause of death in neuromuscular diseases such as muscular dystrophy and amyotrophic lateral sclerosis. Severe muscle loss in cancer leads to serious complications and a poor prognosis. Muscle loss is a natural consequence of aging, similar to bone loss, resulting in decreased muscle strength (frailty), reduced mobility and an increased risk of a fall and broken bones. In metabolic diseases, an imbalance of diet, energy utilization and skeletal muscle leads to poor metabolic function. By increasing muscle mass there is a corresponding decrease in fat mass and improvements in metabolic function.

About ACE-031

ACE-031, a soluble fusion protein based on the activin receptor type IIB (ActRIIB), is a biologic therapeutic that inhibits signaling through the ActRIIB receptor. By preventing signaling through ActRIIB, ACE-031 increases muscle mass and strength. In numerous and varied animal models of disease, ACE-031 significantly increased muscle mass and muscle strength. ACE-031, and a related molecule ACE-435, have shown encouraging preclinical results in animal models of age-related muscle loss, neuromuscular disease, cancer treatment-related muscle loss and metabolic diseases. ACE-031 is currently being studied in a Phase 1 multiple dose clinical trial in healthy volunteers. ACE-435 is expected to enter clinical trials in 2010.

About Acceleron

Acceleron is a privately held biopharmaceutical company committed to discover, develop, manufacture and commercialize novel biotherapeutics that modulate the growth of red blood cells, bone, muscle, fat and the vasculature to treat musculoskeletal, metabolic and cancer-related diseases. Acceleron’s scientific approach takes advantage of its unique insight into the regenerative powers of the TGF-beta superfamily of proteins. ACE-011 is currently being studied in two Phase 2 clinical trials in cancer patients. ACE-031 is currently being studied in a Phase 1 clinical trial in healthy volunteers. In addition, the company is advancing new product candidates that increase muscle mass, control angiogenesis, inhibit fat accumulation and increase hemoglobin. Acceleron utilizes proven biotherapeutic technologies and capitalizes on the company’s internal GMP manufacturing capability to rapidly and efficiently advance its therapeutic programs. The investors in Acceleron include Advanced Technology Ventures, Bessemer Ventures, Celgene, Flagship Ventures, MPM BioEquities, OrbiMed Advisors, Polaris Ventures, QVT Financial, Sutter Hill Ventures and Venrock. For more

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