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We all hope that stem cell is a technic that will cure many deseases,specially MD .
Keep us posted please.

Paul Cliff said:
This sounds like the holy grail. The press release does not say whether there's an accompanying peer-reviewed journal article. Any word on when that'll be published?
Revolutionary stem cell therapy could help fix broken bones

Washington, Jan 9 : By using different new drug combinations, scientists at Imperial College London have tricked bone marrow into releasing specific kinds of adult stem cells into the bloodstream-a technique that in future could be used to repair heart damage or mend a broken bone.

At the time of disease or an injury, a person's bone marrow mobilises different types of stem cells to help repair and regenerate tissue.

Thus, the researchers showed that it may be possible to boost the body's ability to repair itself and speed up repair by using different new drug combinations to put the bone marrow into a state of 'red alert' and send specific kinds of stem cells into action.

In the new study, the bone marrow of healthy mice was tricked into releasing two types of adult stem cells - mesenchymal stem cells.

Such cells could turn into bone and cartilage and can also suppress the immune system, and endothelial progenitor cells, which can make blood vessels and therefore have the potential to repair damage in the heart.

They treated healthy mice with one of two different 'growth factors' - proteins that occur naturally in the bone marrow - called VEGF and G-CSF, after which, the mice were given a new drug called Mozobil.

The study is the first to selectively mobilise mesenchymal stem cells and endothelial progenitor cells from the bone marrow.

This technique is already used in bone marrow transplants in order to boost the numbers of haematopoietic stem cells in a donor's bloodstream.

In the study, the researchers could choose which groups of stem cells the bone marrow released, by using two different therapies.

In the end, the researchers hope to use the new technique to repair and regenerate tissue, for example when a person has heart disease or a sports injury, by mobilising the necessary stem cells.

The researchers also hope that they could tackle autoimmune diseases such as rheumatoid arthritis, where the body is attacked by its own immune system, by kicking the mesenchymal stem cells into action. The stem cells are able to suppress the immune system.

"The body repairs itself all the time. We know that the skin heals over when we cut ourselves and, similarly, inside the body there are stem cells patrolling around and carrying out repair where it's needed. However, when the damage is severe, there are limits to what the body can do of its own accord," said Dr Sara Rankin, the corresponding author of the study from the National Heart & Lung Institute at Imperial College London.

She added: "We hope that by releasing extra stem cells, as we were able to do in mice in our new study, we could potentially call up extra numbers of whichever stem cells the body needs, in order to boost its ability to mend itself and accelerate the repair process. Further down the line, our work could lead to new treatments to fight various diseases and injuries which work by mobilising a person's own stem cells from within."

Now, the scientists are hoping to investigate whether releasing repair stem cells into the blood really does accelerate the rate and degree of tissue regeneration in mice that have had a heart attack.

On the basis of the results of the study, the scientists hope to conduct clinical trials of the new drug combinations in humans within the next ten years.

The researchers are also keen to explore whether ageing or having a disease affects the bone marrow's ability to produce different kinds of adult stem cells.

They want to investigate if the new technique might help to reinvigorate the body's repair mechanisms in older people, to help them fight disease and injury.


London, Jan 9 : British scientists have developed a stem cell treatment that could dramatically boost the body’s ability to repair itself.

The treatment, which makes the bone marrow release a flood of stem cells into the bloodstream, could heal serious tissue damage caused by heart attacks and even repair broken bones.

Scientists already use stem cell therapy to treat leukaemia patients, getting the marrow to release a type of stem cell that can only make fresh blood cells.

Now British researchers say in a study published in the American journal Cell that they have found a way to get the bone marrow to release two other types of stem cell that can repair bone, blood vessels and cartilage.

The bone marrow of treated mice released 100 times as many stem cells, which help to regenerate tissue, said Sara Rankin who led the research team at Imperial College, London.

Rankin said the research has “huge and broad implications”.

"The body repairs itself all the time. However, when the damage is severe, there are limits to what it can do of its own accord.

"We hope that by releasing extra stem cells, as we were able to do in mice in our study, we could potentially call up extra numbers of whichever stem cells the body needs, in order to boost its ability to mend itself and accelerate the repair process,” she said.

"We could potentially call up extra numbers of whichever stem cells the body needs, in order to boost its ability to mend itself and accelerate the repair process."

The group hopes to begin trials later this year to investigate how effective it is at repairing tissue damage in rodents. "All the evidence suggests these cells will make a significant difference to the natural repair process," Rankin said.

Peter Weissberg, medical director at the British Heart Foundation, which co-funded the research along with the Welcome Trust, said: "It now seems increasingly likely that the bone marrow also contains cells that have the capacity to repair damaged internal organs, such as the heart and blood vessels, but that too few of them are released to be effective.

"This research has identified some important molecular pathways involved in mobilising these cells. It may be possible to develop a drug that interacts with these pathways to encourage the right number and type of stem cells to enter the circulation and repair damage to the heart."
Stem Cell Breakthrough: New Method For Creating Stem Cells

ScienceDaily (Mar. 2, 2009) — Mount Sinai Hospital's Dr. Andras Nagy discovered a new method of creating stem cells that could lead to possible cures for devastating diseases including spinal cord injury, macular degeneration, diabetes and Parkinson's disease. The study, published by Nature, accelerates stem cell technology and provides a road map for new clinical approaches to regenerative medicine.
See also:
Health & Medicine

* Stem Cells
* Brain Tumor
* Skin Cancer
* Prostate Cancer
* Lymphoma
* Immune System


* Embryonic stem cell
* Somatic cell
* Stem cell treatments
* Human biology

"We hope that these stem cells will form the basis for treatment for many diseases and conditions that are currently considered incurable," said Dr. Nagy, Senior Investigator at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Investigator at the McEwen Centre for Regenerative Medicine, and Canada Research Chair in Stem Cells and Regeneration. "This new method of generating stem cells does not require embryos as starting points and could be used to generate cells from many adult tissues such as a patient's own skin cells."

Dr. Nagy discovered a new method to create pluripotent stem cells (cells that can develop into most other cell types) without disrupting healthy genes. Dr. Nagy's method uses a novel wrapping procedure to deliver specific genes to reprogram cells into stem cells. Previous approaches required the use of viruses to deliver the required genes, a method that carries the risk of damaging the DNA. Dr. Nagy's method does not require viruses, and so overcomes a major hurdle for the future of safe, personalized stem cell therapies in humans.

"This research is a huge step forward on the path to new stem cell-based therapies and indicates that researchers at the Lunenfeld are at the leading edge of regenerative medicine," said Dr. Jim Woodgett, Director of Research for the Samuel Lunenfeld Research Institute of Mount Sinai Hospital. Regenerative medicine refers to enabling the human body to repair, replace, restore and regenerate its own damaged or diseased cells, tissues and organs.

The research was funded by the Canadian Stem Cell Network and the Juvenile Diabetes Research Foundation (United States).

Dr. Nagy joined Mount Sinai Hospital as a Principal investigator in 1994. In 2005, he created Canada's first embryonic stem cell lines from donated embryos no longer required for reproduction by couples undergoing fertility treatment. That research played a pivotal role in Dr. Nagy's current discovery.

One of the critical components reported in Nagy's paper was developed in the laboratory of Dr. Keisuke Kaji from the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh. Dr. Kaji's findings are also published in the March 1, 2009 issue of Nature. The two papers are highly complementary and further extend Nagy's findings.

"I was very excited when I found stem cell-like cells in my culture dishes. Nobody, including me, thought it was really possible," said Dr. Kaji. "It is a step towards the practical use of reprogrammed cells in medicine."

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